Sudden weight loss

Rapid weight loss can temporarily increase uric acid levels, potentially triggering gout attacks. When the body breaks down fat cells quickly, it releases purines, which are then metabolized into uric acid. This sudden influx of uric acid can overwhelm the kidneys' ability to excrete it efficiently, leading to elevated blood uric acid levels. Additionally, crash diets or fasting can lead to ketosis, which can compete with uric acid for excretion in the kidneys. While weight loss is generally beneficial for gout management in the long term, it's important to lose weight gradually to minimize the risk of triggering attacks. A study published in Arthritis & Rheumatology found that rapid weight loss increased the risk of recurrent gout attacks, even in individuals who were not overweight [1]. References: [1] Nguyen, U. D., Zhang, Y., Louie-Gao, Q., Niu, J., Felson, D. T., LaValley, M. P., & Choi, H. K. (2017). Obesity paradox in recurrent attacks of gout in observational studies: clarification and remedy. Arthritis & Rheumatology, 69(3), 561-565.